石一鸣,研究员,博士生导师。毕业于中国科学院昆明植物研究所药物化学专业,师从孙汉董院士。于德国歌德法兰克福大学开展博士后研究工作,后获马普陆地微生物研究所聘任为Project Group Leader。部分研究成果发表在Nature Chemistry、Nature Chemical Biology、Nature Microbiology和Angewandte Chemie,等期刊上。获国家级青年人才、洪堡奖学金、中科院院长奖、中科院地奥一等奖、中科院优秀毕业生以及博士研究生国家奖学金等奖励和奖项。
研究领域:基于物种相互作用,结合大数据分析和多组学技术,解码自然界的“化学”语言,发现和改造药物先导化合物。
学习经历
2009.09-2014.07,中国科学院大学/昆明植物研究所 药物化学 博士(硕博连读)
2005.09-2009.07,广州中医药大学 药物制剂 学士
工作经历
2023.03-至今,中国科学院深圳先进技术研究院合成生物学研究所,研究员
2021.03-2023.02,马普陆地微生物所,Project Group Leader
2016.01-2021.02,歌德法兰克福大学,博士后
(国际影响力)
1. EMBO | EMBL Symposium: New Approaches and Concepts in Microbiology. Virtual Symposium, Germany, July 2021.
2. MegaSyn symposium. Bad Nauheim, Germany, September 2020.
3. 32nd Irseer Naturstofftage (Natural Product Days). Irseer, Germany, February 2020.
4. 3rd International Conference on Natural Product Discovery and Development in the Genomic Era (Society for Industrial Microbiology and Biotechnology). San Diego, CA, U.S.A, January 2020.
5. International VAAM-Workshop for Biology of Bacteria Producing Natural Products. Frankfurt am Main, Germany, September 2018.
6. 2nd International Conference on Natural Product Discovery and Development in the Genomic Era (Society for Industrial Microbiology and Biotechnology). Clear Water, FL, U.S.A, January 2018.
7. International VAAM-Workshop for Biology of Bacteria Producing Natural Products. Tübingen, Germany, September 2017.
(科研成果)
重大科技项目承担情况:
1.基于物种相互作用的活性天然产物发现,国家高层人才工程计划青年项目,2024-2026,主持。
1. Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria,Nature Chemistry,2022(第一兼通讯作者)。
2. Genome mining enabled by biosynthetic characterization uncovers a widespread class of benzoxazolinate-containing natural products,Angewandte Chemie,2022(第一兼通讯作者)
3. Cleavage off-loading and post-assembly-line conversions yield products with unusual termini during biosynthesis,ACS Chemical Biology,2022(第一兼通讯作者)
4. Dual phenazine gene clusters enable diversification during biosynthesis,Nature Chemical Biology,2019(第一作者)
5. Chassis-independent recombinase-assisted genome engineering enables rapid activation of biosynthetic gene clusters in undomesticated bacteria,Nature Microbiology,2019(共同第一作者)