翟冰博士，中科院深圳先进技术研究院合成生物学研究所研究员，博士生导师，国家重点研发计划青年项目首席科学家。于美国Texas A&M University获得博士学位，随后在纽约Memorial Sloan Kettering Cancer Center完成博士后研究。近五年来研究成果以第一作者或通讯作者发表在Nature Medicine, Nature Microbiology, Current Opinions in Microbiology等感染医学和病原微生物学高水平期刊。研究领域：利用系统生物学与合成生物学方法,研究病原真菌的耐药机制和致病机制，关注人体微生物群落中真菌与细菌的互作关系及其对疾病发生、进展产生的影响。

实验室主页: https://zhailabs.wordpress.com

学习经历：

2008.8-2014.8：美国德克萨斯农工大学 博士

2004.9-2008.6：中国农业大学 本科

工作经历：

2021.4至今：中国科学院深圳先进技术研究院 研究员

2014.12-2021.4：美国纪念斯隆凯特琳癌症中心 博士后、助理研究员

2014.9-2014.11：美国德克萨斯农工大学 博士后

（国际影响力）

1.Resistance & Heteroresistance: Human-associated fungi under prolonged exposure to echinocandin drug in vivo. 32th Fungal Genetics Conference, 2024, Asilomar, California. Plenary session speaker.

2.Echinocandin heteroresistance causes prophylaxis failure and facilitates breakthrough Candida parapsilosis infection. Candida and Candidiasis 2023. Montreal, Canada. Selected oral presentation.

3.Intestinal mycobiome in allogeneic hematopoietic cell transplantation. 31th Fungal Genetics Conference, 2022, Asilomar, California. Concurrent session speaker.

（科研成果）

项目

国家重点研发计划“合成生物学”专项,耐药真菌诊疗的基因回路设计合成,2021.12-2026.11,500万，负责人

1.Bing Zhai,Chen Liao, Siddharth Jaggavarapu, Yuanyuan Tang, Thierry Rolling, Yating Ning, Tianshu Sun, Sean A. Bergin, Mergim Gjonbalaj, Edwin Miranda, N. Esther Babady, Ying Taur, Geraldine Butler, Li Zhang, Joao B. Xavier, David S. Weiss, and Tobias M. Hohl. “Antifungal heteroresistance causes prophylaxis failure and facilitates breakthrough Candida parapsilosis infections.” Nature Medicine (2024).

2.Bing Zhai,Mihaela Ola, Thierry Rolling, Nicholas L Tosini, Sari Joshowitz, Eric R Littmann, Luigi A Amoretti, Emily Fontana, Roberta J Wright, Edwin Miranda, Charlotte A Veelken, Sejal M Morjaria, Jonathan U Peled, Marcel R M van den Brink, N Esther Babady, Geraldine Butler, Ying Taur, Tobias M Hohl. “High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis.” Nature medicine 26, no. 1 (2020): 59-64.

3.Thierry Rolling,Bing Zhai, Mergim Gjonbalaj, Nicholas Tosini, Keiko Yasuma-Mitobe, Emily Fontana, Luigi A Amoretti, Roberta J Wright, Doris M Ponce, Miguel A Perales, Joao B Xavier, Marcel R M van den Brink, Kate A Markey, Jonathan U Peled, Ying Taur, Tobias M Hohl. “Haematopoietic cell transplantation outcomes are linked to intestinal mycobiota dynamics and an expansion of Candida parapsilosis complex species.” Nature microbiology 6, no. 12 (2021): 1505-1515.

4.Yani Fan, Lijuan Wu,Bing Zhai.“The mycobiome: interactions with host and implications in diseases.” Current opinion in microbiology 75,(2023): 102361.

5.Thierry Rolling, Bing Zhai, John Frame, Tobias M. Hohl, and Ying Taur. “Customization of a DADA2-based pipeline for fungal internal transcribed spacer 1 (ITS1) amplicon data sets.” JCI insight 7, no. 1 (2022).